2024年,15項有望改變癌症治療格局的研究

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胶質母细胞瘤（glioblastoma）是一種侵袭性很是高的恶性脑瘤，而且该肿瘤對靶向療法和细胞療法有洗碗手套,着较强的抵当性。《天然》杂志的一篇论文展現了一種名為gliocidin的份子，它具有壮大的血脑屏蔽穿透性，還可以切确地靶向肿瘤细胞，经由過程按捺胶質母细胞瘤DNA和RNA的天生来促成细胞應激和灭亡。别的，gliocidin可以與化療藥物结合利用，這类方法可以或许显著耽误肿瘤小鼠的保存時候，有望成為全新的胶質母细胞瘤醫治计谋。

参考资料：

[1]V. Parreno et al., (2024) Transient loss of Polycomb components induces an epigenetic cancer fate. Nature Doi:

[2]Streptococcus anginosus promotes gastric infla妹妹ation, atrophy, and tumorigenesis in mice. Cell (2024). DOI:

[3]Padmanaban, V., Keller, I., Seltzer, E.S. et al. Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis. Nature 633, 207–215 (2024).

[4]Andrew E Whiteley et al., Breast cancer exploits neural signaling pathways for bone-to-meninges metastasis. Science (2024). DOI: 10.1葉和軒,126/science.adh5548

[5]Zhongyu Zou et al., (2024) RNA m5C oxidation by TET2 regulates chromatin sta油污清潔劑,te and leukaemogenesis. Nature Doi:

[6]Urszula N. Wasko et al., Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer. Nature (2024) Doi:

[7]Joha晚霜推薦,nnes Popow et al., Targeting cancer with small-molecule pan-KRAS degraders. Science (2024). DOI: 10.1126/science.adm8684

[8]Li et al. IGSF8 is an innate i妹妹une checkpoint and cancer i妹妹unotherapy target. Cell (2024).

[9]Shouyan Deng et al., ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor i妹妹une evasion. Cell (2024) Doi:

[10]Zhiliang Bai et al., Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission. Nature (2024) Doi:

[11]Bing Feng et al., The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer. Nature (2024) Doi:

[12]Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers. Nature (2024). DOI:

[13]Mendez-Gomez et al., RNA aggregates harness the danger 刷鍋神器,response for potent cancer i妹妹unotherapy, Cell (2024),

[14]Chen, YJ., Iyer, S.V., Hsieh, D.CC. et al. Gliocidin is a nicotinamide-mimetic prodrug that 排毒清肺湯,targets glioblastoma. Nature (2024).

[15]Maude Jans et al., Colibactin-driven colon cancer requires adhesin-mediated epithelial binding. Nature (2024) Doi: 10.1038/s41586-024-08135-z